How Long Does It Take For Linzess To Get Out Of Your System?

ike Says:

How long does it take for Linzess to be completely out of your system?

39 Replies (2 Pages)

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Sandy Says:

How long does it take linzess to get out of your system?

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David Says:

@ike / sandy,

From what I could gather, Linaclotide (Linzess) doesn't remain in your system very long at all. According to a study on, the parent drug (Linaclotide) completely degrades to its metabolite within 30 minutes, with a first-order half-life of only 3 minutes.

[1] source: PubMed / PMC3638410

That said, my understanding is that Linzess should be completely out of one's system within 1-3 days easy. However there are other important variables outside of the half life that may prolong or otherwise have some sort of impact on the estimated time frame.

Hope this helps!

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Tan Says:

How long does it take for linzess to get out of the body

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Jo Says:

How long does it take for Linzess to get out of your body

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Cathy Says:

Re: Tan (# 3) Expand Referenced Message

I am 115 lbs and i feel the effects of Linzess for at least 2 days. I get bloating and gas. I am now on the 72 MCG but am still feeling after effects.

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Kitty Says:

Re: David (# 2) Expand Referenced Message

Thank you David. I am very worried. My Grandson has had chronic constipation since birth. Dr's tell us to give him mirilax, did. Didn't do any miracles but helped. Now that he's 16 he refuses to take the powder, it's gritty and he says tastes awful. Anyway, my concern now is for 4-3 days he hasn't went, he's very tired, nauseous, been sent home 2 days in a row this week because of feeling tired and feeling bad and nauseous. So I gave him one 145 mcg Linzess capsule tonight at about 8:59pm. He kept trying go before and no go. So I thought the bottle said, do not give to children under age 6. It did. So I gave him one. Then went to read how long before it may work, and read 'don't give to children under 6 at all, or between 6-18 years of age'. I am now freaking out. Please let me know if you think 1 pill will hurt him. As you can see I can not sleep. Appreciate any advice.

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David Says:

Re: Kitty (# 6) Expand Referenced Message

I'm very sorry to hear about your grandson. I hope he's gotten around to feeling better since the timing of your post. Unfortunately, since there's no way of knowing ahead of time how anyone will react/respond to pharmaceutical medications, all I can do is encourage him to consult with a doctor when it comes to prescription drugs such as Linzess... However, I don't know if you heard of Essiac tea leaf, but it works miracles for me and my family whenever serious indigestion occurs, so I just thought I'd mention it as another possible avenue of treatment. I'm actually very hesitant to take it unless the problem is severe because it works almost too well. All you need is an 8oz cup full and it seriously cleans you out like nobody's business, LOL! I believe it is readily available at most health food stores as well as Amazon and other internet retailers. Please let me know if I could be of any more assistance in this matter.

Wishing you both good health always!

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Sassy Says:

Re: Sandy (# 1) Expand Referenced Message

I don't know but I had a allergic reaction after the 3rd pill. It started in my mouth broke out and swelling of the tongue. Couldn't eat for a week.

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Barbara Says:

I'm having cold like symptoms after taking Linzess, how long will these symptoms continue? They are quite annoying.

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Pat Says:

Re: Barbara (# 9) Expand Referenced Message

I am feeling the same way after taking linzess, headache, dizziness, diarrhea, feeling cold.

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Diane Says:

Re: Cathy (# 5) Expand Referenced Message

Very dangerous drug. Just got off. Cover up of this drug

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Karyn Says:

How long does it take for Linzess to leave your system?

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NinaBaker Says:

Re: Pat (# 10) Expand Referenced Message

Same I took 75mg yesterday and I have a headache stomach pains etc. unfortunately this is the only medication that lets me go. But the side effects I get cold shaky I feel like I’m going to pass out I get extremely dizzy I hope I can find something else that works and doesn’t cause so much discomfort.

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AngelaRDH Says:

Re: Diane (# 11) Expand Referenced Message

Please, pretty please, explain!

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Jesse Says:

Re: NinaBaker (# 13) Expand Referenced Message

Iv been on linzess for bout 3 to 4 weeks now and I've had this happening to me. Also so I stopped taking it but I'm still getting the pass out feeling with getting lightheaded and dizzy. Was in the ER for it last night. Pretty scary. How long until that went away for you after u quit taking it?

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Healthy til Linzess Says:

Re: Jesse (# 15) Expand Referenced Message

I have had heart palpitations for 2months since stopping Linzess. I now see a heart doctor as I can't sleep and have dizzy spells regularly. This medicine is evil and causes this problem in 100% of women, 50% of African Americans and 33% people between 50-59. I fall in all categories and don't know when I will recover.

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Barbara Says:

Re: David (# 2) Expand Referenced Message

I have been off of Linzess now for 3 weeks because of bad rectal bleeding! The effects of this drug still has not gone away (severe gas and bloating with very soft stool oozing -- this has been a mess! Never experienced this before the Linzess! I have now had to start to use the very strong anti-diarrhea to try and stop this mess)!

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B Says:

Re: Cathy (# 5) Expand Referenced Message

I also was on the 72... I only took for a week, my symptoms worsened, and even started with bad headaches. Been off for two days and still have headaches.

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Kimberly Says:

How long does it stay in your system and does it clean out your system?

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Arleen Shifrin Says:

How long does it take for linzess to leave your system before beginning another med

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Doris Says:

Re: Kitkat (# 30) Expand Referenced Message

I have been taking 290 mg a day for a month no bad side effects buto just isnt working for me. Does help with bowel movement and still have to strain to g

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Farley Says:

Re: Kitkat (# 30) Expand Referenced Message

Linzess really worked for me after trying everything for over 20 years. Take exactly as directed and yes- lots of water. My only question is- as soon as I started taking it I've been having feelings of sadness/depression. I don't know for sure if it's linked to Linzess. I'm going to stop taking it for about a month and see if there is a correlation. It doesn't seem like there should be for that type of medication. I'm bummed because it has been a life-changing medication for my constipation issue otherwise.

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lisa Says:

Re: B (# 18) Expand Referenced Message

You lose so much water from loose stools you need to HYDRATE TO STOP HEADACHES & DIZZYNESS

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AMTaylor Says:

Re: Susan (# 34) Expand Referenced Message

Was your stomach ache in your actual stomach or abdomen? I have been taking it for a week and my actual stomach hurts.

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Jane Says:

Re: Healthy til Linzess (# 16) Expand Referenced Message

The side effects do not occur in 100% of women. I have never had those side effects. It sometimes doesn’t work but never had cold symptoms or duzziness

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Susan Says:

Re: Sandy (# 1) Expand Referenced Message

I’ve been on 4 months n now I have horrible stomach ache n look 4 months pregnant! I’m stopping

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Burgerboy Says:

Re: NinaBaker (# 13) Expand Referenced Message

I like Dulcolax much better. I take 2 at 3:30 AM, and I go at 9 AM. It is more predictable, and not as harsh as Linzess. I thought I was going to die when on the Linzess. It made me dizzy, and had explosive diarrhea and bad cramps. Never again.

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T Says:

Re: David (# 7) Expand Referenced Message

Nice sales pitch that did not address this womans question. Ma'am please consider bringing him back to a GI specialist and do not pay too much attention to "internet specialists".

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Kitkat Says:

Wow yall. I've been on Linzess for a yr and a half and couldn't live without it. Most of your issues sound like dehydration. The medication is meant to be taken with water and it's recommended that you drink 7 to 8 glasses a day. Diarrhea causes dehydration so any medication you take to initiate a bowel movement can cause headaches etc without proper hydration. You really have to follow the instructions with Linzess for it to work properly. All I know is for me I was in terrible pain before Linzess. It's helped me so much. I take it at bedtime with water and continue to drink water until it works about an hr later then I get a great night's sleep. I'm sorry it hasn't worked for some of you but make sure you're drinking water. If not you'll experience all the symptoms yall have mentioned.

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